Supplements can play a pivotal role in maximizing your gains from weight lifting and athletics. The right supplements can help enhance performance, improve recovery, and increase muscle mass. Here’s a rundown by our medical experts of the best supplements recognized for their effectiveness in supporting muscle growth.
The Short Answer
For anyone looking to maximize muscle growth, the combination of whey protein and creatine monohydrate stands out as the gold standard. Whey protein is unparalleled in its ability to rapidly supply the muscles with high-quality amino acids, essential for muscle repair and growth, particularly after workouts. Creatine, on the other hand, boosts performance by increasing the availability of ATP, which fuels muscle contractions during high-intensity exercises. Together, whey protein and creatine not only enhance your strength and power but also significantly improve muscle recovery and growth. This powerful duo is supported by extensive research and is considered by many as the foundation of an effective supplementation strategy for gaining muscle.
1. Creatine Monohydrate
Creatine monohydrate is perhaps the most extensively studied supplement in the fitness world, renowned for its ability to increase strength and power output. It helps regenerate ATP (adenosine triphosphate), the primary source of energy for muscle contractions, leading to improved performance and increased muscle volume over time. As long as you drink enough water on creatine, you should see a noticeable boost in athletic performace.
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Key Benefits:
- Enhances power and strength
- Supports muscle volumization (Fills muscles with water)
- Accelerates recovery
2. Whey Protein
Whey protein is a fast-digesting protein that provides the body with a high level of amino acids, which are essential for muscle repair and growth. Consuming whey protein post-workout can significantly stimulate muscle protein synthesis, crucial for muscle recovery and growth.
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Key Benefits:
- Supports muscle recovery
- Stimulates muscle protein synthesis
- High in BCAAs (Branched-Chain Amino Acids)
3. Branched-Chain Amino Acids (BCAAs)
BCAAs, particularly leucine, isoleucine, and valine, play a critical role in regulating muscle protein synthesis. Supplementing with BCAAs can help reduce muscle soreness, decrease exercise-induced fatigue, and promote muscle protein synthesis, especially when consumed around your workout.
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Key Benefits:
- Reduces muscle soreness
- Promotes muscle protein synthesis
- Decreases exercise fatigue
4. Beta-Alanine
Beta-alanine is known for its ability to buffer acid in muscles, increasing physical performance and extending the time to exhaustion. Over time, beta-alanine can help increase muscle endurance and lead to slight gains in lean body mass.
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Key Benefits:
- Increases muscular endurance
- Delays muscle fatigue
- Can lead to gains in lean body mass
5. Fish Oil (Omega-3 Fatty Acids)
Omega-3 fatty acids, found in fish oil, have been shown to support muscle recovery and fat loss, as well as reduce inflammation. While not directly linked to muscle growth, their overall benefits to health and recovery can indirectly support muscle-building efforts. If you can find it, krill oil is more effective than fish oil.
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Key Benefits:
- Supports muscle recovery
- Reduces inflammation
- May aid in fat loss
6. Vitamin D
Vitamin D is crucial for muscle function and bone health, and deficiency has been linked to impaired muscle function. Supplementing with vitamin D can support muscle growth, especially in individuals with low blood levels of vitamin D.
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Key Benefits:
- Supports muscle function
- Enhances bone health
- Can improve muscle strength in individuals with Vitamin D deficiency

Best Supplements for Muscle Growth Chart
| Supplement | Description | Key Benefits |
|---|---|---|
| Creatine Monohydrate | A well-researched supplement known for its ability to enhance strength, power output, and muscle volume. It aids in regenerating ATP, essential for muscle contractions. | - Enhances power and strength - Supports muscle volumization - Accelerates recovery |
| Whey Protein | A fast-digesting protein that provides essential amino acids for muscle repair and growth. It's particularly effective when consumed post-workout. | - Supports muscle recovery - Stimulates muscle protein synthesis - High in BCAAs |
| Branched-Chain Amino Acids (BCAAs) | Comprising leucine, isoleucine, and valine, BCAAs help regulate muscle protein synthesis, reduce soreness, and decrease fatigue. | - Reduces muscle soreness - Promotes muscle protein synthesis - Decreases exercise fatigue |
| Beta-Alanine | Known for buffering acid in muscles, this supplement can improve physical performance and extend time to exhaustion, increasing muscle endurance over time. | - Increases muscular endurance - Delays muscle fatigue - Can lead to gains in lean body mass |
| Fish Oil (Omega-3 Fatty Acids) | Rich in omega-3 fatty acids, fish oil supports muscle recovery, fat loss, and reduces inflammation. Krill oil, when available, can be more effective. | - Supports muscle recovery - Reduces inflammation - May aid in fat loss |
| Vitamin D | Essential for muscle function and bone health, supplementing with vitamin D can support muscle growth, especially in individuals with low levels of vitamin D. | - Supports muscle function - Enhances bone health - Can improve muscle strength in individuals with Vitamin D deficiency |




